Dottorato in Neuroscienze - Attività didattica

Piano didattico 35°ciclo

 

Elenco degli insegnamenti offerti nell’a.a. 2019/2020

 I corsi vengono proposti annualmente dai docenti del collegio docenti e attivati in base all’adesione da parte dei dottorandi.

Genetic bases of intellectual disability
Teacher  Angela Bentivegna (Università degli Studi di Milano Bicocca)
Language English
CFU 1
Hours 8
Program To give a comprehensive overview of genetic abnormalities that cause or contribute to intellectual disability (ID).
  Objectives of the course are:
  (a) known genetic causes of ID; (b) the divergent neurodevelopmental phenotypes associated with mutations in some genes; (c) the inheritance patterns observed for the susceptibility to ID, including highly penetrant Mendelian patterns, oligo/polygenic modes of transmission, and sporadic cases due to de novo mutations.
Evaluation YES
Calendar May-June 2020. The course will be activated with a minimum of 4 participants
Glial cells in health and disease
Teacher  Anna Maria Colangelo (Università degli Studi di Milano Bicocca)
Language English
CFU  1
Hours  8
Program  To give a comprehensive overview of the role and function of glial cells in brain function.
  Objectives of the course are:
  Brain metabolism and neuro-metabolic coupling
  Alteration of glial function in neurodegenerative disorders
Evaluation YES
Calendar June 22-23 and 29-30, 2 p.m. – 4 p.m.  (can be adjusted if necessary). The course will be activated with a minimum of 3 participants
Pathways, biomarkers and new therapies in neurodegenerative disorders
Teacher Carlo Ferrarese (Università degli Studi di Milano Bicocca)
Language English
CFU  1
Hours  8
Program  To present current translational research on pathways and biomarkers for early diagnosis and new targeted therapies , the course will focus on: 
  molecular mechanisms of neuronal damage (protein misfolding, excitotoxicity, oxidative stress, neuroinflammation) 
  biomarkers in patients
  new therapeutic trials based on biomarkers
Evaluation YES
Calendar June 2020
Basic Concepts in Neuroinflammation
Teacher  Maria Foti (Università degli Studi di Milano-Bicocca)
Language English
CFU  1
Hours  8
Program  In this course, the diverse and complex interactions between the brain and the immune system from the perspective of current, cutting-edge research papers will be explored.
  The course will provide an extensive knowledge of the role of inflammation in nervous system health and disease. Inflammation is involved in many central nervous system (CNS)-regulated physiological processes (including energy balance, sleep, memory and synaptic plasticity), and is a key host defence response to acute and chronic peripheral and central disorders. Research into neuroinflammation is a major field that aims to develop new therapeutic interventions to treat all major nervous system disorders including stroke, brain trauma, epilepsy, Alzheimer’s disease and neuropathies. This unit will cover the important role of inflammatory molecules as key mediators of CNS functions and will provide basic knowledge on the pathogenesis of, and inflammatory responses to acute and chronic nervous system disorders.
Evaluation YES
Calendar June-July 2020
  The course will be activated with a minimum of 5 participants
Food and brain: Yin and Yan
Teacher  Paola Palestini (Università degli Studi di Milano Bicocca)
Language English
CFU  1
Hours  8
Program  In this cycle of seminars will be presented:
  ·         The principle of heath nutrition 
  ·         The relation between food  and SNC development 
  ·         The good food for nervous system 
  ·         The bad food for nervous system
Evaluation YES
Calendar To be determined according to the overall teaching plan.
  The course will be activated with a minimum of 5 participants
The concept of staminality in neuroscience
Teacher  Arianna Scuteri (Università degli Studi di Milano Bicocca)
Language English
CFU  1
Hours  8
Program  To clarify the “stemness” concept  for the Nervous System and to explore the stem cell potential for research and therapy, the following topics will be addressed:
  ·   The stem cell features
  ·   The stem cells in the Nervous system: neurogenesis
  ·   Methods to potentiate endogenous neurogenesis
  ·   From stem cells to neurons: therapeutic approaches.
Evaluation YES
Calendar September 2020
Neurogenetics
Teacher  Lucio Tremolizzo (Università degli Studi di Milano-Bicocca)
Language English
CFU  1
Hours  8
Program  With the purpose of learning principles of neurogenetics, i.e. genetic applied to neurological and psychiatric disorders, the corse will address the following topics:
  Principles of genetics applied to the field of neuroscience
  Behavioral and cognitive phenotypes
  Motor phenotypes I (strength)
  Motor phenotypes II (quantity/quality of movement)
Evaluation YES
Calendar To be determined according to the overall teaching plan.
  The course will be activated with a minimum of 3 participants
Behavioral test in preclinical neuroscience
Teacher  Gianfranco Caselli (Rottapharm Biotech)
Language English
CFU  1
Hours  12
Program  The aim of this teaching activity is to introduce those students without this background to the basics of behavioral testing in vivo using animal models, focusing on these topics:
  Understanding the basis of behavioral testing in animals
  Observing the application of behavioral testing in healthy animals 
  Observing the application of behavioral testing in animal modles of neuropathic pain
Evaluation NO
Calendar April-May 2020. The course will be activated with a minimum of 2 participants and is limited to a maximum of 5 participants.
Meta-analyses in neurosciences: an introduction
Teacher  Giuseppe Carrà (Università degli Studi di Milano-Bicocca)
Title Meta-analyses in neurosciences: an introduction
Language English
CFU  1
Hours  8
Program  The aim of the course is to acknowledge basic principles and procedures of commonly-used methods for meta-analysis following both PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analyses) and MOOSE (Meta-analysis of Observational Studies in Epidemiology) guidelines.
  The topics addresses in the course are:
  Introduction to epidemiology in neurosciences
  Different measures of association for results synthesis in meta-analysis
  The publication bias issue
  Risk of bias and quality assessment
Evaluation YES
Calendar To be determined according to the overall teaching plan. 
  The course will be activated with a minimum of 3 participants and is limited to 10 participants
Development of diagnostic methods for the evaluation of the response to treatments in preclinical models of glioma
Teacher  Silvia Valtorta (Università degli Studi di Milano-Bicocca)
Language English
CFU  1
Hours  8
Program  To learn fundamentals of research and diagnostic application of imaging in clinical and preclinical field and to learn role of imaging in the monitoring of therapy response. 
  The program will focus on
  - Molecular glioma classification 
  - Neuroinflammation and glioma
  - Creation of preclinical models of glioma
  - Study of tumor heterogeneity using imaging (PET, MRI) 
  - Use of imaging methods for therapy response
Evaluation YES
Calendar May-June 2020
Non-invasive brain stimulation techniques in cognitive neuroscience
Teacher Leonor Josefina Romero Lauro (Università degli Studi di Milano-Bicocca)
Language English
CFU  2
Hours  16
Program  The mechanism of action of three non-invasive brain stimulation techniques: TMS, tDCS and TMS-EEG
  The use of TMS, tDCS and TMS-EEG for research purposes in the field of cognitive neuroscience
  Practical class on tDCS: setting and choosing the stimulation parameters, electrodes montage, electrode positioning according to the 10-20 EEG system.
  Practical class on TMS: setting and choosing the stimulation parameters, determining the resting motor threshold, using the neuronavigation system to guide coil positioning,
  Practical class on TMS-EEG: setting and choosing the stimulation parameters, using the neuronavigation system, collecting one session of TMS-Evoked potentials (TEPs), hints on TEPs data analysis
Evaluation YES
Calendar December 2019 or June 2020. The course will be activated with a minimum of 5 participants and is limited to 10 participants
Basic Mechanism of Epilepsy
Teacher Giulio Sancini (Università degli Studi di Milano-Bicocca)
Language English
CFU  1
Hours  8
Program  The goal is to equip students with the knowledge they need to understand the fundamental concepts underlying current research in the neurophysiology of central circuits. Lectures will allow students to learn how to identify interesting biological questions and feasible approaches to address the questions. 
  Topics of the course are:
  experimental work introduces the student to the main electrophysiological research techniques 
  structure and function of ion channels, generation and propagation of action potential, firing properties and physiology of synaptic transmission
  the hypersynchronous discharge: persistent neuronal changes and circuitry rearrangement
Evaluation YES
Calendar June 2020. The course will be activated with a minimum of 2 participants.
Neuropsychology and Dementias
Teacher  Ildebrando Appollonio and Collaborators (Università degli Studi di Milano Bicocca)
Language English
CFU  2
Hours  24
Program  Foundations of Neuropsychology
  Cognitive Aging and Cognitive Reserve
  Clinical Interpretation of the Psychometric Evaluation 
  Memory, Amnesic syndromes and Alzheimer’s disease
  Executive functions, Fronto-Temporal Lobar Degenerations and Amyotrophic Lateral Sclerosis
  Focal and Degenerative Aphasias, the Agnosias and Semantic Dementia
  Lewy Body Dementia, Cognitive Dysfunction in Parkinson’s Disease and Parkinsonisms
  Alexia and Agraphia, Dyscalculia and Gerstmann’s Syndrome, Apraxias and the Mirror Neurons
Evaluation NO (at least 75% of programmed hour frequency)
Calendar Monday afternoons 2:30-6:30 pm, March and April 2020
Neuropsychology and Dementias: Advanced Course
Teacher  Ildebrando Appollonio and Collaborators (Università degli Studi di Milano Bicocca)
Language English
CFU  1.5
Hours  16
Program  Visuo-Spatial Deficits, Neglect and Posterior Cortical Atrophy (PCA )
  The Agnosias:  from focal lesions to Semantic Dementia (SD)
  Neuropsychology of Aging and Cognitive Reserve 
  Cognitive Decline of Cerebrovascular origin: from vascular dementia (VAD) to vascular cognitive impairment (VCI)
  The Subclinical and Preclinical Phases of progressive cognitive disorders: from full-blown dementia to disease labels (MCI, SCD)
  Rapidly Progressive Dementias
  Behavioral and Psychiatric Disturbances (BPSD) in the Dementias
  Treatment of Non-AD Dementias
  Current Therapies and Research Trials for Alzheimer’s  Disease
Evaluation NO (at least 75% of programmed hour frequency)
Calendar 4 Monday afternoons 2:30-6:30 pm, April and May 2020
  Participants will be admitted till a maximum of 6. First level Neuropsychology and Dementias Course required
Neuropshychology Lab
Teacher  Ildebrando Appollonio and Dr. Cristina Mapelli (Università degli Studi di Milano-Bicocca)
Language English
CFU  1
Hours  12
Program  Practical involvement in neuropsychological approach and research 
  Standard Psychometric Evaluations
  Draft of NPS Reports
  Experimental NPS Approaches
Evaluation NO (at least 75% of programmed hour frequency)
Calendar Date and Time: To be determined, according to Ph. D. overall teaching plan and NPS Lab availability (from January 2020). A maximum of 4 participants will be admitted to the course
Peripheral neuropathies
Teacher  Guido Cavaletti (Università degli Studi di Milano Bicocca)
Language English
CFU  1
Hours  8
Program  The aim of this teaching activity is to introduce those students without a clinical background in neurology to the neurological examination and to the recognition of signs and symptoms of peripheral nerve damage
  Understanding the basis of the neurological examination of the peripheral nervous system
  Assisting to an outpatient clinic activity as observers
  Reporting in summary the results of a clinical assessment of real patients
Evaluation YES
Calendar To be determined according to the overall teaching plan. The course is limited to 3 participants
a cura di Scuola di dottorato, ultimo aggiornamento il 20/10/2019