FACCIOTTI FEDERICA
Biografia
My research group specifically focuses on understanding and functionally manipulating for therapeutic purposes the interactions between the mucosal immune system and the intestinal microenvironment.
The intestinal compartment is a complex biological system composed by different type of cells (immune cells, epithelial cells, gut microbiota) involved in functional crosstalks aimed at maintaining a balance between tolerance and immunity. These interactions may give rise to different functional outcomes. In healthy conditions immune cells contribute to intestinal homeostasis maintenance, while in genetically predisposed individuals hyperactivation of immune cells may lead to in chronic autoimmune intestinal inflammation. In the context of intestinal tumours, defective activation of immune cells may contribute to decreased immunesurveillance and tumour development.
Specifically, our projects focus at:
- Deciphering the role of conventional and unconventional intestinal CD4+T helper cells in contributing to tissue homeostasis and in participating to inflammatory immune responses;
- Understanding the functions of intestinal T lymphocytes in the control of epithelial neoplastic transformations;
- Dissecting the functional interactions between T cells , the gut microbiota and the intestinal microenvironment during intestinal neoplastic transformation and inflammation
- Manipulating the function of immune cells for therapeutic purposes.
To do so, we take advantage of a translational approach involving in vitro systems, murine models of colorectal cancer and intestinal inflammation, and patients’-derived surgical specimens.
Pubblicazioni
Del Vecchio, A., Mule, P., Fernandez-Perez, D., Amato, S., Lattanzi, G., Zanotti, M., et al. (2024). PCGF6 controls murine Tuft cell differentiation via H3K9me2 modification independently of Polycomb repression. DEVELOPMENTAL CELL, 59(3), 368-383 [10.1016/j.devcel.2023.12.015]. Dettaglio
Farini, A., Tripodi, L., Villa, C., Strati, F., Facoetti, A., Baselli, G., et al. (2023). Microbiota dysbiosis influences immune system and muscle pathophysiology of dystrophin-deficient mice. EMBO MOLECULAR MEDICINE, 15(3 (8 March 2023)) [10.15252/emmm.202216244]. Dettaglio
Lopetuso, L., Deleu, S., Godny, L., Petito, V., Puca, P., Facciotti, F., et al. (2023). The first international Rome consensus conference on gut microbiota and faecal microbiota transplantation in inflammatory bowel disease. GUT, 72(9), 1642-1650 [10.1136/gutjnl-2023-329948]. Dettaglio
Noviello, D., Facciotti, F., Caprioli, F. (2023). Environmental protective and risk factors in an at-risk population of subsequent Crohn's Disease. GASTROENTEROLOGY, 164(3 (March 2023)), 500-501 [10.1053/j.gastro.2022.06.050]. Dettaglio
Paroni, M., Leccese, G., Ranzani, V., Moschetti, G., Chiara, M., Perillo, F., et al. (2023). An Intestinal Th17 Subset is Associated with Inflammation in Crohn's Disease and Activated by Adherent-invasive Escherichia coli. JOURNAL OF CROHN'S AND COLITIS, 17(12 (December 2023)), 1988-2001 [10.1093/ecco-jcc/jjad119]. Dettaglio
Progetti di ricerca
Premi e responsabilità scientifiche
Incarichi di insegnamento o ricerca
- Ricercatore universitario a t.d. - Università degli Studi di MILANO-BICOCCA, 2021 - 2024
- Attivita' di insegnamento - Università degli Studi di MILANO-BICOCCA, 2020 - 2021
- Ricercatore presso Ente di ricerca - Istituto Europeo di Oncologia (IRCCS), 2014
- Visiting Researcher - Yale University, 2012 - 2013