FACCIOTTI FEDERICA
Biografia
My research group specifically focuses on understanding and functionally manipulating for therapeutic purposes the interactions between the mucosal immune system and the intestinal microenvironment.
The intestinal compartment is a complex biological system composed by different type of cells (immune cells, epithelial cells, gut microbiota) involved in functional crosstalks aimed at maintaining a balance between tolerance and immunity. These interactions may give rise to different functional outcomes. In healthy conditions immune cells contribute to intestinal homeostasis maintenance, while in genetically predisposed individuals hyperactivation of immune cells may lead to in chronic autoimmune intestinal inflammation. In the context of intestinal tumours, defective activation of immune cells may contribute to decreased immunesurveillance and tumour development.
Specifically, our projects focus at:
- Deciphering the role of conventional and unconventional intestinal CD4+T helper cells in contributing to tissue homeostasis and in participating to inflammatory immune responses;
- Understanding the functions of intestinal T lymphocytes in the control of epithelial neoplastic transformations;
- Dissecting the functional interactions between T cells , the gut microbiota and the intestinal microenvironment during intestinal neoplastic transformation and inflammation
- Manipulating the function of immune cells for therapeutic purposes.
To do so, we take advantage of a translational approach involving in vitro systems, murine models of colorectal cancer and intestinal inflammation, and patients’-derived surgical specimens.
Pubblicazioni
Lattanzi, G., Strati, F., Diaz-Basabe, A., Perillo, F., Amoroso, C., Protti, G., et al. (2026). Corrigendum to “iNKT cell-neutrophil crosstalk promotes colorectal cancer pathogenesis” [Mucosal Immunol. 16(3) (2023) 326–340 [Altro] [10.1016/j.mucimm.2025.11.014]. Dettaglio
Lahner, E., Lenti, M., Massironi, S., Miceli, E., Della Bella, C., Facciotti, F., et al. (2026). Author's reply: “Anti-parietal cell antibodies are more prevalent and clinically relevant in autoimmune endocrine diseases: Comment on the ARIOSO position paper”. DIGESTIVE AND LIVER DISEASE, 58(5), 706-707 [10.1016/j.dld.2026.03.004]. Dettaglio
Maragno, P., Amoroso, C., Conforti, S., Michelon, M., Honcharyuk, I., Ciafardini, C., et al. (2026). The Assessment of Multidimensional Clinical, Biological and Patient-Reported Outcomes to Evaluate the Efficacy of Add-On Lactobacillus rhamnosus GG Supplementation in Mild Ulcerative Colitis: A Randomized Pilot Trial. NUTRIENTS, 18(9) [10.3390/nu18091329]. Dettaglio
Lahner, E., Lenti, M., Massironi, S., Zingone, F., Miceli, E., Della Bella, C., et al. (2026). Autoimmune gastritis: Diagnosis, clinical management and natural history. A position paper by the Autoimmune gastRitis Italian netwOrk Study grOup (ARIOSO). DIGESTIVE AND LIVER DISEASE, 58(1), 38-50 [10.1016/j.dld.2025.10.015]. Dettaglio
Farini, A., Tripodi, L., Villa, C., Strati, F., Facoetti, A., Baselli, G., et al. (2026). Microbiota dysbiosis influences immune system and muscle pathophysiology of dystrophin deficient mice. EMBO MOLECULAR MEDICINE [10.1038/s44321-026-00445-1]. Dettaglio
Progetti di ricerca
Premi e responsabilità scientifiche
Incarichi di insegnamento o ricerca
- Ricercatore/Ricercatrice universitario a t.d. - Università degli Studi di MILANO-BICOCCA, 2024
- Ricercatore/Ricercatrice universitario a t.d. - Università degli Studi di MILANO-BICOCCA, 2021 - 2024
- Attivita' di insegnamento - Università degli Studi di MILANO-BICOCCA, 2020 - 2021
- Ricercatore/Ricercatrice presso Ente di ricerca - Istituto Europeo di Oncologia (IRCCS), 2014
- Visiting Researcher - Yale University, 2012 - 2013