The research activity of F. Peri group (http://www.theperilaboratory.btbs.unimib.it ) spans the fields of organic chemistry, medicinal chemistry and chemical biology. Development of new drug leads: synthetic molecules and natural compounds.
1. Synthesis and biological characterization of small molecules (mainly cationic and anionic glycolipids) able to modulate the activity of the Toll Like Receptor 4 (TLR4) in the perspective to develop new generations of TLR4-directed therapeutics. Synthesis and biological characterization of new molecules active on TLR4 signaling. New anti-inflammatory compounds targeting TLRs, including compounds targeting IBDs, neuro-inflammations, Amyotrophic Lateral Sclerosis (ALS) and Rheumatoid Arthritis. New vaccine adjuvants based on TLR4 agonists.
Coordination of the H2020-funded MSCA-ETN project TOLLerant (“Toll-Like Receptor 4 activation and function in diseases: an integrated chemical-biology approach”, GA number 642157).
2. Synthesis of new steroid derivatives active against hearth failure. Development of drug leads targeting the protein Serca 2a. This project is based on international patents, in collaboration with the company Windtree (USA).
3. Characterization of anti-inflammatory properties of natural compounds from exctracts (coffee, argan oil, etc…)
Funding and grants
2010-2011: Unit coordinator of PRIN grant from Italian Ministry of University and Research (MIUR), title of the project: New multivalent ligands for human galectins as diagnostic and therapeutic agents (3 years grant, 130.000 E for the research unit)
2009-2014: Unit coordinator in the NIH grant AI 59372 “Regulation of MD-2 function and expression”, in collaboration with J. Weiss and T. Gioannini (University of Iowa) (5 years, 50.000 E/year )
2010-2013: Unit coordinator in NEDD grant, design on novel pharmaceutically active compounds (80.000E, 2 years).
2013-2016: Unit coordinator of PRIN grant from Italian Ministry of University and Research (MIUR), title of the project: “Italian network for the development of multivalent nanosystems (MULTINANOITA)” (3 years grant, 53.000 E for the research unit)
2015-2018: Coordinator of Horizon 2020-funded MSCA-ETN project TOLLerant “Toll like Receptor 4 activation and function in diseases: an integrated chemical biology approach”, Grant Agreement number 642157, consortium of 8 academic and 2 industrial groups, 13 ESR recruited in 2015.
2016-2018: PI in the bilateral project with South Korea (prof. Sung You Hung, Ulsan) founded by Italian Ministry of Foreign Affairs (MAECI)
2019-2023: beneficiary of the MSCA-ETN project BactiVax