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MIREYA - Multimodal data Integration and AI-based REsearch on environmental exposures in children and Young Adult cancers
MIREYA is a pan-European, multi-omic, multi-exposures and multi-disciplinary project that advances research and delivers a yet unavailable understanding of the impact and causal pathway of multiple environmental exposures on the development and outcomes in rare children (0-14 years) and adolescent and young… Leggi tutto adults (15-39 years [AYA]) cancers (i.e. embryonal tumours, central nervous system and colorectal cancers). The project will leverage an unparalleled amount of epidemiology datasets from population-based cancer registries from 9 European Countries - collecting data for about 65,000 children and AYA with rare and less studied cancers and more than 500,000 controls – with large pan-European datasets on environmental exposures and socioeconomic position information. These datasets will be integrated with omic data, producing and making available a multisource pan European dataset aligned with the UNCAN and the EHDS platforms. This wealth of data will allow us to identify personalised biological fingerprints of the exposures and define their impact at biological level. Using multilayered research approaches based on reuse, integration and innovative AI-causal-driven analysis of multi-source and multi-disciplinary data (e.g., biological, environmental, social and economic) we will disentangle the combined role of host features and environmental exposures on development and outcomes of cancer in children and AYAs at different stages of life. We will further add to these advances by building the first base of evidence on the potential economic impact of prevention policies aimed at modifiable risks also through social protection measures on cancer inequalities among children and AYAs. This action is part of the Cancer Mission cluster of projects on ‘Understanding (environmental exposure in Children and Adolescent and young adults - CAYAs)
Personalising myasthenia gravis medicine: from “one-fits-all” to patient-specific immunosuppression
CFI - Countering Foreign Interference
In a global context characterised by geostrategic confrontation and competing narratives, information manipulation can be used to influence perceptions on the ground or fuel a conflict by creating confusion. The transition towards a multipolar world, accelerated by recent shocks such as… Leggi tutto the Covid-19 pandemic and the 2022 war Russia has been waging in Ukraine, has created an “informational battleground”, in which malign actors resort to hybrid tools, including Foreign Information Manipulation and Interference (FIMI), to gain influence or undermine the capacities and credibility of other powers. Such a “global battle of narratives” was already described by the EU High Representative for Foreign Affairs and Security Policy/Vice-President of the European Commission (EU HR/VP) Josep Borrell in his 2020’s article3, highlighting the impact the framing of narratives has on citizens’ perceptions and behaviour, governments’ responses and health, economic, political, democratic and security consequences where time is a crucial factor. The 2022 March Strategic Compass (p. 14) warns that the EU now faces “a competition of governance systems accompanied by a real battle of narratives”. In addition, several other key EU communication and policy efforts have already recognised the threat of disinformation and foreign interference, such as the EU Action Plan on disinformation (5 December 2018), the European Democracy Action Plan (3 December 2020), the Digital Services Act (5 July 2022), the Code of Practice on Disinformation (also this year’s (2022) new updated and expanded version), Council Conclusion on Foreign Information Manipulation and Interference (18 July 2022), among others. Therefore, this Action also aims to further the implementation of existing frameworks and promote the related knowledge and tools externally. This action aims to enable the EU to address short and medium-term foreign policy needs and opportunities in and with non-EU territories by supporting innovative policies/initiatives and by deepening EU relations and dialogues, forging alliances and partnerships, in the fields of information manipulation and other types of foreign interference. It will contribute to enhancing the resilience and responses against FIMI, strengthening the EU’s role as a global security provider and defender of democratic values. It will lead to establishing a community of practice, bringing the EU, Member States and partners closer together on the understanding of FIMI-related challenges and how to address them. While the EU has developed over the past few years many new instruments and approaches, gaps in the EU’s ability to address these growing and evolving challenges remain. Therefore, promotion of widespread understanding and visibility of the Union’s work in this domain and its role on the world scene, by means of strategic communication, public diplomacy, people-to-people contacts, cultural diplomacy, cooperation in educational and academic matters, and outreach activities to promote the Union's values and interests will be further enhanced by this Action.