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Sviluppo di modelli cellulari avanzati per lo studio della complessità biologica e per la validazione di terapie innovative

Responsabili: FIANDRA LUISA
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Enti finanziatori: Universita' di Milano Bicocca

SMART-electron- ULTRAFAST ALL-OPTICAL SPATIO-TEMPORAL ELECTRON MODULATORS: OPENING NEWFRONTIERS IN ELECTRON MICROSCOPY

Addressing the grand-challenges that the world is facing nowadays in connection with ‘energy’, ‘information’ and ‘health’ requires the development of unconventional methods for unprecedented visualization of matter. SMARTelectron aims at developing an innovative technological platform for designing, realizing and operating all-optical rapidly-programmable phase Leggi tutto masks for electrons. By introducing a new paradigm where properly synthesized ultrafast electromagnetic fields will be used for engineering the phase space of a free-electron wave function, we will be able to achieve unprecedented space/time/energy/momentum shaping of electron matter waves, surpassing conventional passive monolithic schemes and revolutionizing the way materials are investigated in electron microscopy. Such unique high-speed, flexible and precise full-phase multidimensional control, will enable novel advanced imaging approaches in electron microscopy with enhanced features, such as higher image-resolution, lower electron dose, faster acquisition rate, higher signal-to-noise ratio, and three-dimensional image reconstruction, together with higher temporal resolution and high energy-momentum sensitivity. In SMART-electron, we will make such potential a reality by implementing for the first time three beyond-the-state-of-the-art imaging techniques enabled by our photonicbased electron modulators, namely: (1) Ramsey-type Holography, (2) Electron Single-Pixel Imaging, and (3) Quantum Cathodoluminescence. Such new approaches will lead to unprecedented visualization of many-body states in quantum materials, real-time electrochemical reactions, and spatio-temporal localization of biomimetic nanoparticles in cells for drug delivery. By surpassing the current paradigms in terms of electron manipulation, the project has the potential to drive electron microscopy into a new and exciting age where scientists will benefit from new tools with unprecedented performances that were unimaginable until now.

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Bando: FET-Open Challenging Current Thinking
Enti finanziatori: EUROPEAN COMMISSION

Sviluppo di modelli cellulari avanzati per la validazione di terapie innovative anti-tumorali

Responsabili: FIANDRA LUISA
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Enti finanziatori: Universita' di Milano Bicocca

Impatto di nuovi nanomateriali prodotti a scopo antibatterico o antitumorale sui sistemi biologici: valutazioni tossicologiche in vitro e su vertebrati in via di sviluppo

Responsabili: FIANDRA LUISA
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Enti finanziatori: Universita' di Milano Bicocca

Valutazione della biocompatibilità di nanomateriali diversi tramite saggi tossicologici standardizzati in vitro ed in vivo

Responsabili: FIANDRA LUISA
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Enti finanziatori: Universita' di Milano Bicocca
a cura di Redazione Ricerca, ultimo aggiornamento il 05/05/2026