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OCELOT - iNKT cells immunomodulation and mucosal healing by microbiota-derived
Invariant natural killer T (iNKT) cells are unconventional, CD1d-restricted, T lymphocytes playing a critical role in mucosal immune homeostasis. iNKT cells plastically adapt their functional phenotypes to the surrounding environment and are involved in IBD pathogenesis. Although iNKT cells release… Leggi tutto pro-inflammatory cytokines in response to the altered gut microbiota of IBD patients, exposure to microbiota-derived metabolites can promote homeostatic IL10-mediated iNKT responses resulting in better clinical outcomes in Crohn's disease patients. Thus, understanding the mechanisms leading to iNKT cells’ functional shaping by microbiota-derived metabolites will allow to design novel therapeutic approaches for IBD patients.